ZIA CP010131 10715 (ZIA) | |||
---|---|---|---|
Title | Hemopoietic malignancies among persons exposed to low and moderate ionizing radia | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Little, Mark | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $61,503 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Childhood Cancers (50.0%) |
Hodgkins disease (10.0%) Leukemia (60.0%) Multiple Myeloma (10.0%) Non Hodgkins Lymphoma (20.0%) |
||
Research Type | |||
Resources and Infrastructure Related to Etiology Surveillance |
|||
Abstract | |||
Leukemia is the main sentinel radiogenic malignancy, and is among the most radiogenic of any malignancy. However, it is still somewhat controversial whether low doses of externally administered ionizing radiation can cause leukemia, and in particular whether this is the case for exposure in childhood. By contrast, it appears that most lymphomas, and other hemopoietic malignancies, in particular multiple myeloma, are much less radiogenic. The purpose of this project is to improve our understanding of hemopoietic malignancy risk in relation to radiation exposure at moderate and low doses in childhood. To this end we aim to conduct a pooled analysis of all available epidemiologic cohorts generally externally exposed under the age of 20 or 21; we excluded all groups treated for malignant disease, so that exposures were generally to moderate or low doses (<5 Gy) of ionizing radiation. There are a total of 11 available cohorts. |